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TPO antibodies (TPO-ab) are antibodies directed against thyroid peroxidase, an enzyme essential for the production of thyroid hormones. Elevated levels of TPO antibodies may indicate an autoimmune reaction affecting the thyroid gland and are commonly associated with conditions such as Hashimoto's thyroiditis and Graves' disease. TPO antibodies can sometimes be elevated even when thyroid hormone levels are still within normal ranges.

